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Different Dosages of Corticosteroid and Routes of Administration in Mandibular Third Molar Surgery: a Systematic Review J Oral Maxillofac Res 2018;9(2):e1 doi:10.5037/jomr.2018.9201 Abstract | HTML | PDF | XML |
Different Dosages of Corticosteroid and Routes of Administration in Mandibular Third Molar Surgery: a Systematic Review
1Department of Oral and Maxillofacial Surgery, Aalborg University Hospital, Aalborg, Denmark.
2Department of Oral and Maxillofacial Surgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
3Unit of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.
Corresponding Author:
Department of Oral and Maxillofacial Surgery
Aalborg University Hospital
18-22 Hobrovej, DK-9000 Aalborg
Denmark
Phone: +45 97 66 27 95
Fax: +45 97 66 28 25
E-mail: marie.kjaergaard@rn.dk
ABSTRACT
Objectives: The objective of the present systematic review was to test the hypothesis of no difference in facial swelling, pain and trismus after surgical removal of mandibular third molar with different dosages of corticosteroids and administration routes.
Material and Methods: A MEDLINE (PubMed), Embase database and Cochrane Library search in combination with a hand-search of relevant journals was conducted by including randomized controlled trials published in English until 1st December 2017.
Results: Seven studies fulfilled the inclusion criteria. Considerable variation in the included studies prevented meta-analysis from being performed. Preoperative submucosal injection of corticosteroids significantly diminishes facial swelling, pain and trismus compared with placebo. However, different dosages of corticosteroid and administration routes reveal contrary results indicating that administration of a higher dosage of corticosteroids do not necessarily cause a further decrease in facial swelling, pain and trismus.
Conclusions: Consequently, the optimal dosage of corticosteroids and administration route for diminishing postsurgical morbidity and improve quality of life after surgical removal of mandibular third molar is presently unknown. Therefore, further well-designed randomized clinical trials including a standardised protocol, patient-reported outcome measures and three-dimensional analysis of facial swelling is needed.
J Oral Maxillofac Res 2018;9(2):e1
doi: 10.5037/jomr.2018.9201
Accepted for publication: 25 June 2018
Keywords: corticosteroids; dentistry; edema; molar; pain; trismus.
To cite this article: Different Dosages of Corticosteroid and Routes of Administration in Mandibular Third Molar Surgery: a Systematic Review J Oral Maxillofac Res 2018;9(2):e1 URL: http://www.ejomr.org/JOMR/archives/2018/2/e1/v9n2e1ht.htm |
Received: 8 May 2018 | Accepted: 25 June 2018 | Published: 29 June 2018
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2018.