Study Patients
(n) 		Sockets
(n) 		Smoking patients IS pathology Age
(years) 		Site Follow-up
(months) 		Implant system
Montoya-Salazar et al. [18] 18 36 (IS:18, NIS:18 Included Chronic periapical lesion 18 - 50 Incisors, canines and premolars 36 MIS C1 implants (MIS Implants Technologies Ltd.; Tel Aviv, Israel)
Jung et al. [19] 27 27 (IS:12, NIS:15) Included Periapical pathologies 31 - 87 (IS) 28 - 82 (NIS) Incisors, canines and premolars 60 Straumann® Standard Plus or Tapered Effect (Straumann AG; Basal, Switzerland)
Crespi et al. [20] 37 275 (IS:197, NIS:78) Heavy smokers excluded
(> 10 cigarettes/day) 		Chronic periodontal lesions 32 - 71 Incisors, canines and premolars 48 Sweden and Martina SPA, Due Carrare, Padova, Italy
Crespi et al. [21] 30 30 (IS:15, NIS:15) Heavy smokers excluded
(> 10 cigarettes/day) 		Periapical lesions and radiolucencies 34 - 71 Incisors, canines and premolars 24 Seven (Sweden and Martina SPA, Due Carrare, Padova, Italy)
Hita-Iglesias et al. [22] 60 168 (IS:66, NIS:102) Non-smokers only Chronic periapical lesions 18 - 72 Incisors, canines and premolars 12 Zimmer dental, USA
Blus et al. [23] 86 168 (IS:83, NIS:85) No data Acute and chronic infection 26 - 77 Incisors, canines and premolars 12 Leader Implants; Milan, Italy or and Bioner Sistemas Implantológicos, Barcelona, Spain
Bell et al. [24] 655 922 (IS:285, NIS:637) Included Chronic periapical lesion Mean: 58.4 IS; 60.1 NIS Incisors, canines, premolars and molars 3 - 93 Straumann® Tissue Level or Bone Level SLA (Straumann AG; Basal, Switzerland)
Fugazzotto [25] 64 128 (IS:64, NIS:64) Heavy smokers excluded
(> 10 cigarettes/day) 		Periapical pathologies 21 - 71 Incisors 24 - 117 No data
Zuffetti et al. [26] 369 527 (IS:193, NIS:334) Heavy smokers included
(> 10 cigarettes/day) 		Chronic infection 22.8 - 81.9 Incisors, canines, premolars and molars Mean 52.1 BIOMET 3i® (BIOMET 3i LLC; Palm Beach Gardens, Florida, USA).
Biohorizons® (BioHorizons Inc; Birmingham, Alabama, USA).
Nobel Biocare AG; Zürich, Switzerland.
Astra Tech Implant System™ (Dentsply Sirona; Göteborg/Mölndal, Sweden).
MegaGen Implant Co. Limited; Gyeong-buk, South Korea.
Neoss AB; Göteborg, Sweden.

n = numbers; IS = infected socket; NIS = non-infected socket; ASA = The American Society of Anaesthesiologists physical status classification system.