Inclusion criteria Exclusion criteria
- Bilateral symmetrical impacted mandibular third molars.
- Indication for removal of mandibular third molars.
- Age between 18 and 40 years. 		- Acute infection in the oral cavity at the time of surgery.
- Previous maxillofacial trauma.
- Craniofacial clefts or syndromes.
- Systemic bone disease (i.e. arthritis) or diabetes mellitus.
- Active acne vulgaris, viral and fungal infections.
- Psychological disease.
- Medication as bisphosphonate, anticoagulants and other drugs that have an influence on corticosteroids.
- Pregnancy and breastfeeding.
- Failure to attend follow-up.
- Known allergy to methylprednisolone and other inactive ingredients.