Studies HPF Giant cells Nuclei/giant cell Fractional surface area Relative size index
Aggressive Non-aggressive Aggressive Non-aggressive Aggressive Non-aggressive Aggressive Non-aggressive
Choung et al. [1] 20 134 233 - - 4.6% 7.8% 4.1 3.4
Reddy et al. [7] 25 164.6 121.3 9.8 8.1 8.5 4.9 5.1 3.8
Kruse-Losler et al. [15] 25 160.6 115.3 9.5 7.8 8.2% 4.4% 5.3 3.9
Ficarra et al. [16] 25 42.7 23.31 6.89 6.4 0.087 0.041 0.198 0.163

CGCG = central giant cell granuloma; HPF = high power field.