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Frequency and Clinical Significance of Incidental Findings on CBCT Imaging: a Retrospective Analysis of Full-Volume Scans J Oral Maxillofac Res 2024;15(1):e5 doi:10.5037/jomr.2024.15105 Abstract | HTML | PDF | XML |
Frequency and Clinical Significance of Incidental Findings on CBCT Imaging: a Retrospective Analysis of Full-Volume Scans
1Department of Preventive Dentistry - Periodontology and Implant Biology, Aristotle University of Thessaloniki, 3 Kavalas Str., 565625, Sykies, Thessaloniki, Greece. Email: ht_auth.dent@yahoo.com
2Department of Oral Diagnosis and Radiology, Dental School of Athens, National and Kapodistrian University of Athens, 2 Thivon Str, 11527, Goudi, Athens, Greece. Email: sdamask@dent.uoa.gr
3Department of Oral Diagnosis and Radiology, Dental School of Athens, National and Kapodistrian University of Athens, 2 Thivon Str, 11527, Goudi, Athens, Greece. Email: angelopoulosc@gmail.com
Corresponding Author:
Department of Oral Diagnosis and Radiology, Dental School of Athens
National and Kapodistrian University of Athens
2 Thivon Str, 11527, Goudi, Athens
Greece
Phone: +30 210 2713402
Fax: +30 6944541529
E-mail: sdamask@dent.uoa.gr
ABSTRACT
Objectives: This retrospective study aims to identify incidental findings in cone-beam computed tomography scans of patients irradiated for preoperative evaluation for implant placement and obtained using the same imaging unit as well as the same field of view. The incidence of each incidental finding, as well as the overall incidence, were calculated and the findings were ranked according to their clinical significance.
Material and Methods: A total of 741 cone-beam computed tomography (CBCT) examinations with extended field of view (15 x 15 cm) were retrospectively evaluated for incidental findings (IFs). These were identified, recorded, classified as to their location, and ranked according to their clinical significance.
Results: The vast majority of CBCT examinations presented at least one IF, resulting in a surprisingly high prevalence in total. If extreme anatomical variants are considered (nasal septum deviation, sinus septations etc.), the cumulative prevalence exceeds 99%. IFs of major significance, that may require immediate attention, are beyond 10% in frequency.
Conclusions: We found high prevalence of incidental findings on cone-beam computed tomography examinations performed for preoperative evaluation for implant placement (99.5% if anatomical variants included). Most incidental findings were of minor significance. Although the number of incidental findings that require immediate attention is relatively low, there is a considerable number of cases that need periodic evaluation and/or referral.
J Oral Maxillofac Res 2024;15(1):e5
doi: 10.5037/jomr.2024.15105
Accepted for publication: 31 March 2024
Keywords: clinical relevance; cone-beam computed tomography; dental implants; incidental findings.
INTRODUCTION
Given the inherent limitations of two-dimensional approach in dental imaging, the advent of cone-beam computed tomography (CBCT) with the multi-planar imaging of the craniomaxillofacial complex that it provides, gave rise to significantly increased diagnostic accuracy and validity in oral and maxillofacial radiology [1]. Therefore, this increase, obtained due to the three-dimensional visualization of the structures of this anatomical area, has led to the identification of radiological findings largely incidental and, more or less unexpected, in relation to the reason for performing the radiological examination [2]. Some of these incidental findings (IFs) are easily recognizable and can be identified by anatomical and radiological criteria (e.g., mucosal thickening, tonsilolliths, etc.). On the other hand, such an IF presence could cause a diagnostic dilemma, which may require further investigation through additional clinical assessment, different imaging methods and/or paraclinical tests [2,3].
Such IFs are also present - to a different extent for each imaging modality - in medical radiology. A classic example of such an IF is the identification of pulmonary nodules during examination of a chest X-ray or, more commonly, a medical computed tomography (CT) scan that includes the lungs [4]. In the systematic review of 26 multi-slice computed tomography (MSCT) studies by Lumbreras et al. [4], which covered the entire spectrum of imaging diagnostic tests in medicine, the mean overall frequency of IFs in MSCT was found to be 31.1% (95% CI [confidence interval] = 20.1 to 41.9%). Also, worth mentioning is the multicentre study by Rogers et al. [5], in which the prevalence of IFs in 15831 MSCT examinations of the head was found to be up to 4%. Wisely, the authors acknowledged the legal and bioethical aspects that arise when managing and reporting these findings to patients and their families.
Despite the inability of CBCT to clearly present soft tissue, compared to MSCT, on account of its lower contrast resolution, and hence its probable decreased capacity towards distinguishing of findings among soft tissue differences, the detection frequency of IFs on CBCT is not inferior to that of MSCT, since it usually exceeds 50% [3,6-19].
The existing diversity among IFs that can be found on CBCT examinations covers a wide range of irradiated structures. These are both, the maxilla and the mandible, paranasal sinuses, nose, pharynx and upper airway, temporomandibular joints (TMJ), skull base, facial bones, spine, and the soft and hard tissues of the neck. These findings can be classified based on their anatomic location and clinical significance [2].
The present retrospective study aims to identify incidental findings in cone-beam computed tomography scans of patients irradiated for preoperative evaluation for implant placement, having been obtained by using the same imaging unit as well as the same field of view. The incidence of each incidental finding, as well as the overall incidence, were calculated and the findings were ranked according to their clinical significance.
MATERIAL AND METHODS
Subjects
A total of 1049 full-volume (15 x 15 cm, field of view [FOV]) CBCT examinations were performed at the Aristotle University of Thessaloniki (Thessaloniki, Greece) in patients older than 18 years for routine radiographic evaluation before implant surgery, from May 5, 2014 to May 31, 2017, were included in this study. Informed consent was obtained prior to all clinical and imaging procedures. In total 1049 CBCT scans were selected and retrospectively evaluated. Of these, 308 scans, with poor diagnostic information due to artifacts presence were excluded from this study (Figure 1). Ultimately, a total of 741 CBCT examinations that met the inclusion and exclusion criteria were evaluated. All CBCT examinations were submitted for interpretation to a radiologic interpretation and reporting service (Maxillofacial Radiology Consultants©; New York, NY, USA). Due to the retrospective nature of this study, ethical approval was not required from the Aristotle University of Thessaloniki.
Figure 1 |
CBCT imaging
All patients were irradiated by the same dental imaging unit - Galileos® Comfort Plus three-dimensional CBCT scanner (Sirona Dental Systems Inc.; Bensheim, Hessen, Germany) - using the units fixed kV and mA exposure parameters (85 KVp, 5 to 7 mA, FOV 15 x 15 x 15 [spherical volume], voxel size 300 μm), for all examinations. All CBCT scans were evaluated using Invivo™ 6 software (Anatomage; San Jose, CA, USA). After the image reconstruction, 1 mm-thick transverse, coronal, and sagittal sections of both, the maxilla and mandible, as well as panoramic and cross-sectional ones were created. When the TMJs were visible, the 1 mm-thick coronal and sagittal imaging sections of the left and right articulations were also reconstructed.
Evaluation of the CBCT images
For each of the 741 CBCT exams, the interpretation of the entire image volume was carried out by the same dentist C.A. (oral radiology specialist, certified by the American Board of Oral and Maxillofacial Radiology). He recorded the findings per anatomical region, in special medical opinions with a standardized structure by Maxillofacial Radiology Consultants©. These opinions reported the findings, also classified by anatomic region and specifically into findings located in the maxilla, mandible, nose and paranasal cavities, spine, neck, and TMJ structures, as well as the relevant recommendations.
Retrospectively, these opinion-based radiological findings were assessed, standardized, and recorded as qualitative variables in processed tables/worksheets of Microsoft 365® online program Excel (Microsoft Corporation; Washington, USA) by two independent examiners (C.T., S.D.). The standardization and classification of the findings in specific cells for each category was carried out after discussion and consensus of the researchers. Thus, the following variables were created:
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Gender;
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IFs referring to nose, paranasal sinuses, TMJs and endocranium (Table 1);
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IFs referring to mouth floor, cervical spine, and neck (Table 2);
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IFs of minor significance;
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IFs of intermediate significance;
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IFs of major significance (Table 3).
Table 1 |
Table 2 |
Table 3 |
Since all patients were primarily referred for CBCT examination due to preoperative evaluation for implant placement, findings of dental or periodontal origin were excluded from further analysis as they were not considered “incidental”.
Statistical analysis
The IFs reported in Tables 1 and 2 were statistically processed using IBM® SPSS® Statistics for Windows version 23.0 (IBM Corp.; Armonk, New York, USA) and the frequency and relative frequency of each finding was calculated separately. In cases where TMJ was not visible in the CBCT-volume, the corresponding variables were considered as missing values, and these cases were not considered for the overall calculation of the frequencies associated with the incidental TMJ findings.
RESULTS
Out of the 741 patients who underwent CBCT examination, 329 (44.4%) were males and 412 were females (55.6%). The total number of IFs detected in all CBCT scans was 2715 findings in 741 patients, showing an average of 3.66 findings per patient. Only 81 out of 741 patients (10.93%) were found without any pathological IF. If several anatomical variations such as scoliosis/deviation of the nasal septum, sinus hypoplasia and/or aplasia and bony septa of the paranasal sinuses are taken into account, then only 4 patients do not present IFs; with the overall incidence of findings reaching up to 99.5%.
The frequencies and relative frequencies of pathologic IFs, as well as anatomic variations identified in the anatomical regions of the nose, paranasal sinuses, cranial sinuses, and endocranium are presented in Table 4. The frequencies and relative frequencies of TMJ-related findings were calculated based on a sample of 663 TMJs, since only these were sufficiently depicted in the CBCT tomographic field.
Table 4 |
Accordingly, all the frequencies and IFs, as well as anatomic variations identified in the anatomical regions of the floor of the mouth, spine, and neck are presented in Table 5.
Table 5 |
All detected IFs were classified into 3 categories, according to their clinical significance. Thus, IFs of low clinical significance do not require further action; IFs of moderate clinical significance usually require follow-up and occasionally referral; and finally, IFs of high clinical significance require immediate attention and appropriate referral/intervention. Table 3 illustrates the classification of detected IFs according to their clinical significance. Furthermore, representative IFs images of high clinical significance are shown in Figures 2 and 3.
Figure 2 |
Figure 3 |
DISCUSSION
It is reasonable to expect that CBCT may reveal more diagnostic information than the relevant two-dimensional images, resulting in a rapidly increasing perspective in dental radiology [7]; as the frequency of the type of IFs has been shown to increase with increasing FOV [20]. Interestingly, in our retrospective study of CBCT scans of patients referred for evaluation of implant placement, IFs were observed at a high overall frequency. More in detail, out of a total of 741 CBCT examinations, a number of 2715 IFs - including anatomical variations - were identified. This indicates a number of 3.6 IFs per patient, whereas Price et al. [8] found 3.2 IFS per patient, and Edwards et al. [14] found that these IFs ranged from 1.3 to 2.9 IFs per CBCT scan.
In particular, only 81 CBCT scans were found without IFs outside the area of interest, this amounts to 89.07% of the cases. If the various anatomical variations are added to the above percentage, then 99.5% of the CBCT examinations investigated showed at least one IF. It’s worth noting that only 4 patients out of 741 did not present any IF. However, the most prevalent IFs identified in our study were the nasal septum deviation (82.5%), sinus mucosal thickening (48.3%), airway narrowing (37.7%), conchae bullosa (15.3%) and nasal mucosal thickening (14.5%), being generally findings with not such high clinical significance.
Previous studies on CBCT scans have also shown an IF prevalence of 80 to 90%, even though smaller FOVs were used [2,7,11-13,14,16,18,19]. Our results are also consistent with those of Price et al. [8], Cağlayan et al. [2] and Edwards et al. [14] who reported that the airway was the zone with the highest number of IFs in CBCT examinations, albeit the reported sample-sizes were quite limited. On the other hand, Cha et al. [7] and Rheem et al. [13] reported much lower IFs incidence in CBCT scans (26.4% and 40.1% respectively), while Drage et al. [16] and Pilska et al. [9] reported an IF incidence of 65%. The reported lower incidence of IFs in the aforementioned studies is attributed to a variety of factors, such as the size of the FOV used. In particular, Drage et al. [16] performed their study using CBCT scans obtained with a 4 x 4 FOV, while Rheem et al. [13] used various FOV sizes to calculate the final frequency. As previously stated, the frequency of the type of incidental findings has been shown to increase with increasing FOV [20], so using a limited FOV, such as 5 x 5 x 6, and/or 8 x 8 x 8 cm, may result in revelation of fewer IFs. That being said, it is noteworthy to report that, due to the single imaging unit used (Galileos® Comfort Plus), the FOV used in our study was 15 x 15 cm (spherical volume) in all of the included scans. Consequently, identifying all possible IFs that may be present in a single volume, results in a most pragmatic approach for each individual patient.
Nevertheless, our findings are in line with past systematic review findings, indicative of high rates of IFs detection; As a matter of fact, the most cited systematic reviews, those of Edwards et al. [21] and Dief et al. [20], found a comparable frequency in the presence of IFs ranging from 24.6 to 93.4%. Thus, the authors concluded that the presence of IFs in CBCT examinations is relatively common and characterized by significant variations in its frequency and nature, which may be attributed - at least partly - to differences in the individual populations sampled in the included studies.
Similarly to CBCT, a multicentre study in 15831 children head MSCT examinations - due to head trauma - showed IFs in 4% of them. Of these, 30% warranted immediate intervention or outpatient follow-up. It should be mentioned that the authors did not include findings consistent with inflammation in the paranasal sinuses and especially sinusitis findings, considering that these findings are particularly common in the paediatric and adolescent population [5].
Regarding the clinical significance of our findings, they are detailed in Table 3, and their frequencies and relative frequencies in Tables 4 and 5. Existing research suggests that although IFs of high clinical significance on CBCT are relatively rare [16], their existence and overall impact, in terms of requiring follow-up and/or interventions, warrants further investigation [15]. It is worth noting that dealing with an IF, unrelated to the reason of referral, is a controversial issue that implicates the core of medicine, law, and bioethics [22-25].
On one hand, patients have the inalienable "right to know" and in this sense, the health care provider must inform the patient about any finding of an examination method that concerns him, providing him with the full information he is entitled to [26]. Thus, dental radiologists should inform patients, despite any adverse consequences that may arise, as ultimately the patient is solely responsible for making any decision, and this autonomy should be respected [25,26]. A common paradigm of such a case is the identification of radiopacities compatible with the presence of calcifications within the carotid lumen either intra- or extra-cranially (Figure 2). As the presence of carotid plaque, when assessed, may be associated with an increased risk of stroke and coronary heart disease-related events, typically independent of other major cardiovascular risk factors [27]. Similarly, the radiographic differential diagnosis of an enlarged sella turcica (Figure 3) includes several pathologic conditions, most commonly, a primary intrasellar pituitary tumour [28].
On the other hand, the abundance of medical information may eventually not benefit the patient, and there are literature recommendations indicative of a more “discreet” management of IFs with respect to patient information [2]. More specifically, benign, and insignificant IFs (e.g. tonsiloliths, etc.) might not be mentioned, since such unnecessary and superfluous knowledge may finally harm the patient in terms of increased anxiety and financial cost, leading to overdiagnosis and overtreatment [29,30].
Along the same lines as above, we only emphasize that the soft tissue pathology on osseous borders, airway asymmetry, enlarged sella and carotid artery calcification(s) found in our study; are IFs of high potential clinical significance, with extracranial calcified carotid artery atheroma being the most prevalent one (10.3%).
CONCLUSIONS
A high prevalence of incidental findings is observed on cone-beam computed tomography examinations performed for preoperative evaluation for implant placement (99.5% if anatomical variants included). Their vast majority were of minor significance, not requiring further examination or referral. Although the number of incidental findings that require immediate attention is relatively low, there is a considerable number of cases that need periodic evaluation. It is crucial that clinicians interpret the total volume obtained in cone-beam computed tomography examinations and report when in doubt.
ACKNOWLEDGMENTS AND DISCLOSURE STATEMENTS
The authors report no conflicts of interest related to this study.
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To cite this article: Frequency and Clinical Significance of Incidental Findings on CBCT Imaging: a Retrospective Analysis of Full-Volume Scans J Oral Maxillofac Res 2024;15(1):e5 URL: http://www.ejomr.org/JOMR/archives/2024/1/e5/v15n1e5ht.htm |
Received: 27 March 2024 | Accepted: 31 March 2024 | Published: 31 March 2024
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2024.