SRM3 with A-PRF
(No. 40) 		SRM3 with NSH
(No. 40) 		P-valuea
Gender (female/male) 24/16 26/14 0.64
Age at the time of
surgery (year) 		Mean (SD) 32.2 (7.7) 33.4 (9) 0.52
Range 20; 51 20; 55
Smoking (≥ 10 cigarettes per day) 3 2 0.6
Alcohol (> 7 units per week) 2 1 0.56
48/38 (FDI dental notation) 22/17 13/27 0.04*
Body mass index Mean (SD) 26.3 (4.4) 26.8 (4.5) 0.63
Range 20.2; 39 19.5; 37
DMFT index Mean (SD) 4.4 (4.3) 6.6 (5.9) 0.06
Range 0; 17 0; 19
Nervous for SRM3
(VAS: 0 - 100) 		Mean (SD) 40.2 (28.1) 42.3 (32.5) 0.77
Range 0; 100 0; 100
MDAS Mean (SD) 9 (3.4) 11 (5.5) 0.06
Range 5; 18 4; 25
Education Elementary school 4 6 0.19
High school 8 14
University 28 20
Employment Student 8 7 0.56
Homebound 1 1
Employment 31 30
Unemployment 0 2
Indication
for SRM3 		Pain 25 22 0.45
Pain and infection/swelling 10 14
Decay 5 4
Radiographic
signs of pathology 		Radiolucency 28 22 0.02*
Decay 8 4
None 4 14
Pell and Gregory's
classification 		IA/IIA/IIIA 2/9/0 0/8/0 0.2
IB/IIB/IIIB 6/13/8 4/21/6 0.32
IC/IIC/IIIC 0/2/0 0/0/1 0.08
PASS-20 Total score Mean (SD) 25 (18.1) 22.7 (14.5) 0.62
Range 0; 89 0; 61
Cognitive Mean (SD) 10.2 (5.7) 10.4 (5.9) 0.76
Range 0; 25 0; 22
Escape/
avoidance 		Mean (SD) 6.6 (4.8) 6.5 (4.3) 0.96
Range 0; 21 0; 15
Fear Mean (SD) 3.9 (5.2) 3.0 (4.5) 0.34
Range 0; 19 0; 20
Physiological
anxiety 		Mean (SD) 4.1 (4.9) 2.9 (3.3) 0.23
Range 0; 24 0; 14

aChi-square tests for categorical data and t-test for continuous data. *Statistically significant at P < 0.05.
A-PRF = advanced platelet-rich fibrin; DMFT = Decayed Missing Filled Teeth index; PASS = Pain Anxiety Symptoms Scale; NSH = natural socket healing; SD = standard deviation; SRM3 = surgical removal of an impacted mandibular third molar.