Wound healing SRM3 with A-PRF SRM3 with NSH Differences P-valuea
Time Mean (95% CI) Mean (95% CI) MD (95% CI)
T1 4.1 (3.9; 4.2) 4.1 (3.9; 4.2) -0 (-0.2; 0.2) 1.00
T2 4.9 (4.8; 5) 4.9 (4.8; 4.9) 0 (-0.1; 0.2) 0.45
T3 5 (4.9; 5) 5 (4.9; 5.1) -0 (-0.1; 0.1) 0.89

aStatistically significant at P < 0.05 (Wald test in mixed regression).
A-PRF = advanced platelet-rich fibrin; CI = confidence interval; MD = mean difference; NSH = natural socket healing; SRM3 = surgical removal of an impacted mandibular third molar.