IMO SRM3 with A-PRF SRM3 with NSH Differences P-valuea
Time Mean (95% CI) Mean (95% CI) MD (95% CI)
T0 50 (48.4; 51.5) 49.2 (47.4; 50.9) 0.8 (-1.5; 3.1) 0.5
T1 42.5 (39.9; 45.2) 43.7 (41.8; 45.5) -1.1 (-4.3; 2.1) 0.49
T2 50.8 (49.2; 52.4) 49.4 (47.9; 50.9) 1.4 (-0.8; 3.6) 0.2
T3 53.4 (51.7; 55.1) 51.8 (50.8; 53.5) 1.7 (-0.8; 4.1) 0.18

aStatistically significant at P < 0.05 (Wald test in mixed regression).
A-PRF = advanced platelet-rich fibrin; CI = confidence interval; IMO = interincisal mouth opening; MD = mean difference; NSH = natural socket healing; SRM3 = surgical removal of an impacted mandibular third molar.